Yuji Itadori and Satoru Gojo: Yuji, the protagonist, shares a mentor-student relationship with Satoru Gojo, his Jujutsu Sorcerer teacher.
Megumi Fushiguro and Nobara Kugisaki: Megumi and Nobara are Yuji's close friends and fellow students at Tokyo Jujutsu High. Their friendship is characterized by mutual respect and trust.
Yuji Itadori and his Grandfather: Although Yuji's grandfather's appearance is brief in the series, their relationship is significant.
Yuta Okkotsu and Rika Orimoto: Yuta and Rika share a unique relationship. Rika is Yuta's deceased childhood friend, whose cursed spirit is bound to him.
Toge Inumaki and Panda: Toge Inumaki, known for his ability to communicate only in simple phrases, has a close friendship with Panda, a mysterious and powerful cursed corpse.
Suguru Geto and Mahito: While not a "best" relationship, the dynamic between Suguru Geto and Mahito is one of the most complex and intriguing in the series.
Satoru Gojo and Kento Nanami: Gojo and Nanami are two skilled Jujutsu Sorcerers who work together to combat curses and protect humanity.